If you’re craving a hearty, crowd-pleasing dish that combines bold flavors with comforting textures, the John Wayne Casserole Recipe is about to become your new go-to. This casserole layers savory ground beef seasoned with zesty taco spices over flaky biscuits, topped with creamy mayo-sour cream, and melted cheese for a dish that feels like a warm hug on a plate. It’s simple enough for a weeknight dinner but impressive enough to serve friends and family on special occasions.

Ingredients You’ll Need
Gathering the right ingredients for this recipe is straightforward but essential—each component plays a perfect role in building those iconic layers of taste, texture, and bursts of color that make the John Wayne Casserole Recipe so memorable.
- 16 ounces refrigerated large biscuits: These create a fluffy, buttery base that soaks up all the savory juices.
- 1 tablespoon olive oil: For sautéing vegetables and adding a subtle richness.
- 2 pounds ground beef: The hearty protein foundation packed with flavor.
- 1 packet taco seasoning: Brings that unmistakable Southwest spice that wakes up your taste buds.
- ¼ – ½ cup water: Helps blend the seasoning and keep the beef mixture moist.
- 10 ounces diced tomatoes with green chilies: Adds a tangy, mildly spicy twist with lovely texture.
- 14 ounces canned corn (drained): Sweetness and crunch to balance the savoriness.
- 1 onion (sliced): Provides foundational savory flavor and slight sweetness when sautéed.
- 1 red bell pepper (sliced): Bright color and a crisp, mild pepper bite.
- 4 ounces canned sliced jalapenos: For those perfect spicy little kicks in every bite.
- 1 cup mayonnaise: Adds creaminess and richness that elevates the casserole’s texture.
- 1 cup sour cream: Brings a subtle tang that balances all the bold flavors.
- 1 cup shredded cheddar cheese: Sharp and melty cheese that adds classic comfort.
- 1 cup shredded mozzarella cheese: For gooey, luscious meltiness topping the dish.
- Fresh parsley (chopped, for garnish): A fresh, vibrant touch to brighten the final presentation.
How to Make John Wayne Casserole Recipe
Step 1: Prepare the Biscuit Base
Start by preheating your oven to 350°F (175°C) and lightly greasing a 9×13 inch baking dish. Lay out the refrigerated biscuits in a single, even layer, pressing them gently together to form a biscuit crust. Pop them in the oven for about 10 to 12 minutes so they partially bake and set—this will help build a sturdy, slightly crisp base for your casserole.
Step 2: Sauté the Veggies and Brown the Beef
While the biscuits are baking, heat olive oil in a large skillet over medium heat. Toss in the sliced onion and red bell pepper, sautéing until they become tender and slightly caramelized. Add the ground beef, cooking thoroughly until it’s browned all over. Be sure to drain any excess fat to keep things from getting greasy.
Step 3: Season and Simmer the Beef Mixture
Sprinkle the taco seasoning evenly over the cooked beef and veggies, then add between ¼ to ½ cup of water. Stir well to combine and let it simmer for a bit. Next, fold in the diced tomatoes with green chilies along with the drained corn. Cook this mixture for about 5 minutes, allowing all the flavors to blend wonderfully.
Step 4: Layer the Beef Mixture on the Biscuit Crust
Remove your partially baked biscuit base from the oven and spread the seasoned beef mixture evenly across it. Make sure the layer is well distributed, so every bite gets that perfect combination of biscuit and savory filling. Then, scatter the sliced jalapenos evenly on top for a welcome spicy punch.
Step 5: Add the Creamy Layer
In a separate bowl, mix together the mayonnaise and sour cream until smooth. Spread this luscious cream topping over the jalapenos, covering the entire surface. This layer will add richness and help balance the heat with smooth creaminess.
Step 6: Top with Cheese
Sprinkle shredded cheddar and mozzarella cheeses evenly over the creamy layer. This double-cheese topping melts beautifully into gooey, golden perfection, sealing all the flavors inside while adding a delectably cheesy crust.
Step 7: Bake to Perfection
Pop the assembled casserole into your preheated oven and bake for 30 to 35 minutes. You’ll know it’s done when the cheese is bubbly and golden, and the biscuit base is fully cooked through, with just the right amount of crispy edges.
Step 8: Garnish and Serve
Once out of the oven, let the casserole cool a few minutes. Sprinkle chopped fresh parsley over the top for a burst of color and freshness before serving warm. This final touch brightens and balances the richness of the John Wayne Casserole Recipe beautifully.
How to Serve John Wayne Casserole Recipe

Garnishes
Fresh parsley is my go-to garnish for this casserole because it adds a lovely verdant contrast and a hint of herbaceous brightness. If you feel adventurous, a dollop of guacamole or a sprinkle of diced green onions can also give a magnificent finishing touch.
Side Dishes
This casserole is a meal in itself but pairs delightfully with simple sides like a crisp green salad or roasted vegetables. For something heartier, a bowl of black beans or a serving of Spanish rice will round out your meal with complementary textures and flavors.
Creative Ways to Present
Make your John Wayne Casserole Recipe sparkle on the table by serving it in individual ramekins for a personal touch, or layer it in clear glass casseroles to showcase the beautiful strata of ingredients. You can also top each serving with fresh avocado slices or a drizzle of hot sauce for added flair.
Make Ahead and Storage
Storing Leftovers
Store any leftover John Wayne Casserole Recipe in an airtight container in the refrigerator. It will stay fresh for up to 3 days, making it perfect for quick lunches or dinner leftovers that reheat wonderfully.
Freezing
This casserole freezes exceptionally well. After baking and cooling completely, wrap it tightly with plastic wrap and foil or place in a freezer-safe container. Frozen leftovers can be kept for up to 2 months and thawed overnight in the fridge before reheating.
Reheating
To reheat, cover the casserole with foil and warm it in a 350°F oven for about 20 minutes or until heated through. For single servings, a microwave works fine, but for best texture, the oven method preserves the crispness of the biscuit base and melts the cheese perfectly.
FAQs
Can I use homemade biscuits instead of refrigerated ones?
Absolutely! Homemade biscuits add an extra layer of freshness and flavor. Just make sure they are large and sturdy enough to hold the filling well.
Is there a way to make this casserole less spicy?
Yes, simply reduce or omit the canned jalapenos and use mild diced tomatoes instead of ones with green chilies. You can always add a bit of spice at the table with hot sauce if you like.
Can I substitute ground turkey or chicken for ground beef?
Definitely. Ground turkey or chicken will create a lighter version of this dish, although you might want to adjust the seasoning slightly to maintain robust flavor.
Is the mayonnaise and sour cream layer necessary?
While optional, this creamy layer is a key component that balances the bold spices and adds richness, making the John Wayne Casserole Recipe truly special. You can experiment, but I recommend keeping it.
How can I make this more of a one-pot meal?
Use an oven-safe skillet or Dutch oven large enough to brown the beef and assemble the layers right inside. This saves on dishes and simplifies cleanup.
Final Thoughts
This John Wayne Casserole Recipe is a guaranteed crowd-pleaser, packing big flavors with comforting textures in every bite. Whether you’re cooking for family, friends, or just yourself, it’s a hearty, satisfying dish that’s easy to prepare and impossible not to love. Give it a try soon—you’ll wonder how it ever wasn’t a staple in your kitchen before!
Print
John Wayne Casserole Recipe
- Prep Time: 20 minutes
- Cook Time: 45 minutes
- Total Time: 1 hour 5 minutes
- Yield: 8 servings
- Category: Casserole
- Method: Baking
- Cuisine: American, Tex-Mex
Description
John Wayne Casserole is a hearty, flavorful layered dish featuring a base of partially baked biscuits topped with a savory seasoned ground beef mixture, fresh vegetables, creamy mayo-sour cream sauce, and melted cheddar and mozzarella cheese. This one-dish meal combines Tex-Mex flavors with comfort food, perfect for family dinners or casual gatherings.
Ingredients
Base
- 16 ounces refrigerated large biscuits
Beef Mixture
- 1 tablespoon olive oil
- 2 pounds ground beef
- 1 packet taco seasoning
- ¼ – ½ cup water
- 10 ounces diced tomatoes with green chilies
- 14 ounces canned corn, drained
- 1 onion, sliced
- 1 red bell pepper, sliced
- 4 ounces canned sliced jalapenos
Creamy Layer
- 1 cup mayonnaise
- 1 cup sour cream
Cheese Topping
- 1 cup shredded cheddar cheese
- 1 cup shredded mozzarella cheese
Garnish
- Fresh parsley, chopped
Instructions
- Preheat and prepare biscuit base: Preheat the oven to 350°F (175°C) and lightly grease a 9×13 inch baking dish. Arrange the refrigerated biscuits in a single layer, pressing them slightly to cover the bottom evenly. Bake for 10-12 minutes to partially cook the biscuits.
- Sauté vegetables and brown beef: Heat olive oil in a large skillet over medium heat. Add the sliced onion and red bell pepper and sauté until softened. Add the ground beef and cook until browned, then drain any excess fat.
- Add seasoning and vegetables to beef: Stir in the taco seasoning and ¼ to ½ cup water, mixing thoroughly. Add diced tomatoes with green chilies and drained corn. Cook for about 5 minutes to blend flavors.
- Assemble beef layer: Spread the beef mixture evenly over the partially baked biscuits in the baking dish. Scatter the sliced jalapenos evenly on top of the beef.
- Prepare creamy layer: In a separate bowl, combine mayonnaise and sour cream. Spread this mixture evenly over the jalapenos to create a smooth creamy layer.
- Add cheese topping: Sprinkle shredded cheddar and mozzarella cheeses evenly over the creamy layer to cover completely.
- Bake the casserole: Place the assembled casserole in the preheated oven and bake for 30-35 minutes until the cheese is bubbly, golden, and the biscuits are fully cooked through.
- Finish and serve: Remove the casserole from the oven and let it cool for a few minutes. Garnish with chopped fresh parsley. Serve warm and enjoy this hearty casserole.
Notes
- Partial baking of the biscuit base ensures it cooks through during the final bake without becoming soggy.
- Adjust jalapeno quantity to control heat level to taste.
- For a lighter option, use reduced-fat mayonnaise and sour cream.
- Make sure to drain excess fat from the beef to avoid a greasy casserole.
- This dish can be prepared a day ahead and baked just before serving for convenience.

